Carol Feghali-Bostwick Selected Research

Insulin-Like Growth Factor Binding Protein 5

11/2021	Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5.
12/2020	Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5.
1/2018	IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators.
1/2015	IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.

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Carol Feghali-Bostwick Research Topics

Disease

36	Fibrosis (Cirrhosis) 12/2021 - 10/2008
22	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2021 - 10/2008
14	Systemic Scleroderma (Systemic Sclerosis) 12/2021 - 07/2003
13	Idiopathic Pulmonary Fibrosis 01/2020 - 01/2013
8	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 09/2012
7	Lung Diseases (Lung Disease) 11/2020 - 10/2008
5	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 10/2008
3	Disease Progression 12/2017 - 01/2014
3	Lung Injury 01/2017 - 10/2008
2	Inflammation (Inflammations) 11/2020 - 06/2019
2	Vascular Remodeling 06/2013 - 03/2011
1	Pneumonia (Pneumonitis) 01/2019
1	Sclerosis 01/2019
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2019
1	Pulmonary Arterial Hypertension 05/2017
1	Neoplasms (Cancer) 04/2016
1	Cicatrix (Scar) 04/2016
1	Respiratory Insufficiency (Respiratory Failure) 04/2016
1	Body Weight (Weight, Body) 10/2015
1	Chronic Disease (Chronic Diseases) 10/2015
1	Asthma (Bronchial Asthma) 01/2014
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2014

Drug/Important Bio-Agent (IBA)

16	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 09/2012
13	Proteins (Proteins, Gene)FDA Link 11/2021 - 10/2008
5	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 05/2011
4	Insulin-Like Growth Factor Binding Protein 5IBA 11/2021 - 01/2015
4	CytokinesIBA 11/2020 - 01/2013
4	CollagenIBA 11/2020 - 10/2008
4	PeriostinIBA 01/2020 - 01/2014
4	MicroRNAs (MicroRNA)IBA 11/2018 - 04/2015
3	Insulin-Like Growth Factor Binding ProteinsIBA 11/2021 - 01/2015
3	Peptides (Polypeptides)IBA 01/2021 - 10/2015
3	Transcription Factors (Transcription Factor)IBA 06/2013 - 10/2008
2	EndostatinsIBA 12/2021 - 10/2015
2	Messenger RNA (mRNA)IBA 01/2021 - 12/2015
2	Fibronectins (Fibronectin)IBA 01/2021 - 01/2017
2	indium-bleomycinIBA 01/2021 - 01/2019
2	Biological ProductsIBA 11/2020 - 03/2019
2	IntegrinsIBA 01/2020 - 01/2020
2	CP-4715IBA 01/2020 - 01/2020
2	Interleukin-17 (Interleukin 17)IBA 06/2019 - 01/2013
2	Insulin-Like PeptidesIBA 03/2019 - 01/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 03/2011
2	Mitochondrial DNA (mtDNA)IBA 01/2019 - 12/2017
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 12/2018 - 01/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 01/2017
2	Pharmaceutical PreparationsIBA 05/2017 - 01/2016
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 10/2013
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2016 - 01/2013
2	Beclin-1IBA 12/2015 - 03/2011
1	EnzymesIBA 12/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2021
1	sulfoxideIBA 11/2020
1	AllergensIBA 11/2020
1	Member 25 Tumor Necrosis Factor ReceptorsIBA 11/2020
1	Indicators and Reagents (Reagents)IBA 11/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Interleukin-22 (IL-22)IBA 06/2019
1	InterleukinsIBA 06/2019
1	Insulin-Like Growth Factor Binding Protein 4IBA 03/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019
1	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2019
1	Phospholipase DIBA 01/2019
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2019
1	anti-scl-70 autoantibodiesIBA 01/2019
1	1-dodecylpyridoxal (PLD)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Peptide Hydrolases (Proteases)FDA Link 01/2019
1	HydrogelsIBA 01/2018
1	Superoxides (Superoxide)IBA 11/2017
1	NADPH Oxidase 4IBA 11/2017
1	Vasodilator Agents (Vasodilators)IBA 05/2017
1	Sirtuin 3IBA 05/2017
1	Interleukin-8 (Interleukin 8)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	Dinoprostone (PGE2)FDA Link 01/2017
1	Synaptotagmins (Synaptotagmin)IBA 12/2016
1	plexinIBA 12/2016
1	Serine Proteases (Serine Protease)IBA 04/2016
1	Matrix Metalloproteinases (MMPs)IBA 04/2016
1	ErbB Receptors (EGF Receptor)IBA 01/2016
1	TenascinIBA 01/2016
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 01/2016
1	lysophosphatidic acidIBA 01/2016
1	Extracellular Matrix ProteinsIBA 12/2015
1	sphingosine 1-phosphate lyase (aldolase)IBA 12/2015
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2015
1	Hydroxyproline (4 Hydroxyproline)IBA 10/2015
1	Mutant Proteins (Protein, Mutant)IBA 02/2015
1	NucleolinIBA 01/2015
1	Proto-Oncogene Proteins c-metIBA 03/2014
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 03/2014
1	Vitamin D FDA LinkGeneric 01/2014
1	RoflumilastIBA 10/2013
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 06/2013

Therapy/Procedure

13	Therapeutics 12/2021 - 05/2011
1	Organ Transplantation 01/2018
1	Lung Transplantation 04/2016
1	Oral Administration 10/2015